Multiple IVF failures: Why and What to do?

A number of physiological conditions represent causes leading to IVF failures:

Increasing maternal age, decreased number of oocyte collected by surgical aspiration, decreased availability of transferable mature eggs, decreased quality of embryos, elevated FSH levels, poor response to fertility medication, unexplained infertility, variation in experience & medical infrastructure at embryology lab.

Reduced endometrial thickening & autoimmune responses in endometrial receptivity also has potential to create multiple IVF failures. A change in approach after IVF failures mandates a change in one of the factors such as a different surrogate in next IVF cycle run. The success rates in IVF can be improved with use of advance diagnostic methods such as Pre Genetic Diagnosis (PGD) or Assisted Embryo Hatching to choose best and viable embryos. Active monitoring for chromosomal aberrations can prevent medical termination of pregnancy in IVF cycles.

Human growth hormone in combination with FSH & LH is used to create favorable conditions in IVF cycle run to create healthier pregnancies. A proper medical testing ensures detection of main reason of multiple IVF failures. The remedial treatment steps include improvement of ovarian stimulation with hormonal injections, to ensure better ovulation rate and better oocyte retrieval.

The implementation of advance embryological methods Zygote Intrafallopian Transfer, Gamete Intrafallopian Transfer, Frozen Embryo transfer are other approaches in case of persistent failure with multiple IVF cycles.

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